Big time, a paradigm shift has happened.
1 - Internet & Mobile tech has taken over everything. Whatever business you are in, if you are not online, you are losing 50% of sales right away to begin with
2 - Today's business is not about selling, it is about adding value, solving people's problems, back in the 80s customers heard about the products in the store for the very first time, but now customers have done enough research, analysis, even window shopped, gotten their hands on & even tested and clearly know which product is the best and how does it work and to what degree it meets their requirements by the time they get their hands on the product at the store, so your product really needs to add value in a significant way and that is only possible by clearly knowing what your target market is and how you are helping them solve their problem
3 - And this young millennial market are so technology savvy, if you are not extending your product in the form of an app or through some online medium in some fashion it is not going to engage them very well
4 - Globalization - wherever you go you are going to engage with people from other countries and other cultures that are helping you with services or manufacturing or could be your potential customers - so incorporate an aspect of multi culturalism in your corporate structure. Soon no company will have their own office space, it will be people from all over the world working for different companies sitting from their home offices and collaborating through monitors and video conferences via high bandwidth internet connections
5 - Everything has accelerated, the speed of messaging, the speed of manufacturing, the speed of distribution, the speed of delivery, the speed of everything
These are some very very high level points to think about. Having said the basics are still the same, business is done through trust, winning the confidence of your customer, through relationships etc. The delivery channels and the pace has changed quite a bit.
Also check out my book Puga Sankara's Supply Chain Blog - that is a must read before spending Hundreds & Thousands of $$$ on your MBA or Masters Degree to get the best ROI or before starting your Entrepreneurial journey.